Post-doc position – Structural Bioinformatics of protein interactions
Are you passionate about deciphering the mysteries of life through computational analysis? Do you possess a keen interest in structural biology and its implications in drug discovery and biomolecular function? We are looking for an experienced postdoctoral researcher with a strong background in modelling of proteins and their interactions, including using empirical force fields, like FoldX.
What is the project all about?
We are coordinating a large interdisciplinary project to develop a new generation of protein engineering and design tools, with the goal of designing protein-protein interactions. Our work, which aims to have a direct impact on drug discovery and has a strong valorization angle, makes strong use of the FoldX force field, and related tools, such as ModelX and TANGO. As always, our work starts from a thorough analysis of existing protein structures, to extract rules and databases of working examples, and from there implement novel design approaches.
The job:
Together with the PIs of the Switch Lab you will be part of a team that is developing new tools to analyze and predict protein-protein interactions. You will be well supported on an administrative level, allowing you to focus on the science, both hands-on in the lab and analyzing data.
Responsibilities:
• Utilize computational tools and techniques to model and analyze the structure and function of proteins and protein complexes. • Employ and enhance our innovative tools for protein-ligand docking, and structure-based protein design. • Develop and implement algorithms and pipelines for structural bioinformatics analyses. • Collaborate with experimentalists to integrate computational and experimental data. • Stay abreast of the latest developments in structural biology and bioinformatics.
Requirements:
• Ph.D. or Master's degree in Bioinformatics, Computational Biology, Structural Biology, or related field. • Proficiency in programming languages such as Python, R, C++, or Perl. • Experience with molecular modeling software (e.g., FoldX, Schrödinger Suite, Rosetta). • Strong understanding of structural biology principles and techniques. • Excellent communication skills and ability to work collaboratively in a multidisciplinary team.
Preferred Qualifications:
• Familiarity with empirical force fields • Experience with high-performance computing clusters. • Track record of publications in structural bioinformatics or related fields.
What we offer:
- A vibrant, world-class research environment operating at an international level
- State of the art research facilities.
- Administrative support (orders, reporting, ethical approvals, etc.) so that you can focus on the project
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Access to the resources of two host institutions:
VIB, an excellence-based research institute
KU Leuven, one of Europe’s leading research universities
- A vibrant, world-class research environment operating at an international level
- A dedicated training program to broaden your expertise and enhance your skillset.
- At SWITCH, we pay particular attention to our people's career development goals and actively support our lab members' ambitions in the lab and beyond. You can see here where our alumni are now.
- A competitive compensation package based on expertise and experience
Starting Date:
as soon as possible
How to apply?
Please complete the online application procedure and include a detailed CV, including a list of publications, a motivation letter, and the contact information of at least two referees.
Contact hannah.wilkinson@kuleuven.be if you need more information.
