Houben, B. et al. EMBO Journal 39(11), e102864, 2020
Gatekeepers attenuate the aggregation of aggregation-prone regions (APRs) present in most proteins. Our recent paper shows that not all Gatekeeper residues are created equal. Chaperones have a preference for positively charged Gatekeeper residues, because these need a little more help than negatively charged Gatekeepers.
Read the VIB press release here: https://vib.be/news/why-chaperones-favor-basic-residues
Read the full paper here (open access): https://www-embopress-org.kuleuven.ezproxy.kuleuven.be/doi/full/10.15252/embj.2019102864