Louros, N., et al. Nature Communications 11, 3314, 2020

Not all amyloids are hydrophobic...

Cordax, our recently published structure-based amyloid core sequence prediction method aided by machine learning identified amyloid-forming sequences beyond the traditional limits of sequence determinants of amyloid propensity. Cordax found surface-exposed fragments in proteins that are quite soluble yet can form amyloid fibres.

You can read the paper here (open access): https://www.nature.com/articles/s41467-020-17207-3