Post Doc - Selective Vulnerability in Alzheimer's Disease
Do you want to help find out what is really going on in Alzheimer's disease? Why does the disease sweep through the brain in such a determined manner? Why do amyloid aggregates form in certain brain regions and not others? Why are some brain regions devastated and others spared?
In our previous work we have identified a new mode of amyloid interactions based on local sequence similarity to aggregation prone regions and the National Institute on Aging has just granted us a 5-year project to investigate the interaction of amyloid-beta and tau with other brain region-specific proteins.
The project entails:
- a genome-wide computational screen for specific (heterotypic) interactions between the aggregation-prone regions of amyloid-forming proteins and the background proteome
- testing the candidate proteins in cellular models and then in mice
- biophysical analyses to discern the exact mechanism by which heterotypic interactions change amyloid formation.
We’re looking for a post doc to join a growing team to take this project to fruition.
- A PhD in a topic related to protein aggregation /protein biophysics
- A keen interest in protein aggregation and its role in disease
- Expertise in biophysical or biochemical methods to study protein aggregation
- A high affinity for bioinformatics
- A solid publication record
- Highly motivated, enthusiastic, critical, and creative
- Excellent written and oral communication skills
- Can supervise doctoral/master's students
- Can work in a multidisciplinary and multicultural team
- Experience with mammalian cell culture or high-content screening is a plus
What we offer:
- A 4-year+ timeline at a world-renowned institution
- State of the art research facilities.
- Administrative support (orders, reporting, ethical approvals, etc.) so that you can focus on the project
Access to the resources of two host institutions:
VIB, an excellence-based research institute
KU Leuven, one of Europe’s leading research universities
- A vibrant, world-class research environment operating at an international level
- A dedicated training program to broaden your expertise and enhance your skillset.
- At SWITCH, we pay particular attention to our people's career development goals and actively support our lab members' ambitions in the lab and beyond. You can see here where our alumni are now.
- A competitive compensation package based on expertise and experience
as soon as possible
How to apply?
Please complete the online application procedure and include a detailed CV, including a list of publications, a motivation letter, and the contact information of three referees.
Contact email@example.com if you need more information.