Wu G, et al. Cell Chem Biol 28 (4):524-536 e524. 2021

Can bacteria evade the effects of antimicrobial Pept-ins?

In this paper, we investigated the mechanism of action of aggregation-inducing Pept-ins by studying Peptin resistance mechanisms. We found that electrostatic attraction between the negatively charged bacterial membrane and the positively charged Pept-ins facilitate Pept-in uptake which likely involves many transporters.

You can read the paper here: https://www.sciencedirect.com/science/article/pii/S2451945620305171?via%3Dihub