Langenberg et al., Cell Reports 31, 107512, April 14, 2020
Once, a long time ago, we may have been all amyloids...
Our recent paper shows that the stability of the amyloidogenic segments buried in the native structure of globular proteins are thermodynamically linked to the stability of the globular protein itself. Although it is possible to remove the amyloidogenic segments from a globular protein (e.g. the tumour supressor p53) and keep the native structure of the protein, the genetic code makes such change very unlikely. In other words, once an amyloidogenic segment is formed, the sequence is stuck, which leads to the deeps conservation of these sequences.
Our results also suggest that amyloids may predate globular proteins.
You can read the paper here (open access): https://www.sciencedirect.com/science/article/pii/S2211124720304022