Amyloids Fibrillize, or Stay Solo, Based on Liaisons with Like Proteins
A summary on AlzForum.org discusses two of our papers on the heterotypic interactions of amyloid-beta and tau amyloids with other proteins.
The discussed papers:
Konstantoulea K, Guerreiro P, et al. Heterotypic Amyloid β interactions facilitate amyloid assembly and modify amyloid structure. The EMBO Journal (2022) 41:e108591
Louros N, et al. Mapping the sequence specificity of heterotypic amyloid interactions enables the identification of aggregation modifiers. Nature Communications (2022) 13 (1):1351