Mapping aggregation-specific interactions in human disease

Newest publications

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  A guide to studying protein aggregation

  Joëlle A J Housmans, Guiqin Wu, Joost Schymkowitz, Frederic Rousseau

  FEBS J . 2021 Dec 4

  PubMed
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  Heterotypic amyloid interactions: Clues to polymorphic bias and selective cellular vulnerability?

  Nikolaos Louros, Joost Schymkowitz, Frederic Rousseau

  Curr Opin Struct Biol . 2021 Dec 20

  PubMed
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  Heterotypic Amyloid β interactions facilitate amyloid assembly and modify amyloid structure

  Katerina Konstantoulea, Patricia Guerreiro, Meine Ramakers, Nikolaos Louros, Liam D Aubrey, Bert Houben, Emiel Michiels, Matthias De Vleeschouwer, Yulia Lampi, Luís F Ribeiro, Joris de Wit, Wei-Feng Xue, Joost Schymkowitz, Frederic Rousseau

  EMBO J . 2021 Nov 29

  PubMed
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  Highly efficient intercellular spreading of protein misfolding mediated by viral ligand-receptor interactions

  Shu Liu, André Hossinger, Stefanie-Elisabeth Heumüller, Annika Hornberger, Oleksandra Buravlova, Katerina Konstantoulea, Stephan A Müller, Lydia Paulsen, Frederic Rousseau, Joost Schymkowitz, Stefan F Lichtenthaler, Manuela Neumann, Philip Denner, Ina M Vorberg

  Nat Commun . 2021 Oct 19

  PubMed
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  Bcl-xL acts as an inhibitor of IP 3 R channels, thereby antagonizing Ca 2+-driven apoptosis

  Nicolas Rosa, Hristina Ivanova , Larry E Wagner 2nd, Justin Kale, Rita La Rovere, Kirsten Welkenhuyzen, Nikolaos Louros, Spyridoula Karamanou, Victoria Shabardina, Irma Lemmens, Elien Vandermarliere, Kozo Hamada , Hideaki Ando, Frederic Rousseau, Joost Schymkowitz, Jan Tavernier, Katsuhiko Mikoshiba, Anastassios Economou, David W Andrews, Jan B Parys, David I Yule, Geert Bultynck

  Cell Death Differ . 2021 Nov 8

  PubMed
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  The cellular modifier MOAG-4/SERF drives amyloid formation through charge complementation

  Anita Pras, Bert Houben, Francesco A Aprile, Renée Seinstra, Rodrigo Gallardo, Leen Janssen, Wytse Hogewerf, Christian Gallrein, Matthias De Vleeschouwer, Alejandro Mata-Cabana, Mandy Koopman, Esther Stroo, Minke de Vries, Samantha Louise Edwards, Janine Kirstein, Michele Vendruscolo, Salvatore Fabio Falsone, Frederic Rousseau, Joost Schymkowitz, Ellen A A Nollen

  EMBO J . 2021 Oct 7;e107568

  PubMed