Welcome to the Switch Laboratory

Mapping aggregation-specific interactions in human disease

Our research focuses on understanding the mechanisms gearing protein folding and misfolding and their relation to human disease. In particular, we are investigating how protein aggregation affects the interactome by suppressing native interactions but also by introducing novel aggregation-specific interactions. These latter are especially relevant as they are usually associated with gain of function activities such as neurotoxicity (neurodegeneration).

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Newest publications

  • publication

    Pharmacological modulation of septins restores calcium homeostasis and is neuroprotective in models of Alzheimer's disease

    Katrien Princen , Tom Van Dooren, Marit van Gorsel, Nikolaos Louros, Xiaojuan Yang, Michael Dumbacher, Ilse Bastiaens, Kristel Coupet, Shana Dupont, Eva Cuveliers, Annick Lauwers, Mohamed Laghmouchi, Thomas Vanwelden, Sofie Carmans, Nele Van Damme, Hein Duhamel, Seppe Vansteenkiste, Jovan Prerad, Karolien Pipeleers, Olivier Rodiers, Liese De Ridder, Sofie Claes, Yoni Busschots, Lentel Pringels, Vanessa Verhelst, Eveline Debroux, Marinka Brouwer, Sam Lievens, Jan Tavernier, Melissa Farinelli, Sandrine Hughes-Asceri, Marieke Voets, Joris Winderickx, Stefaan Wera, Joris de Wit, Joost Schymkowitz, Frederic Rousseau, Henrik Zetterberg, Jeffrey L Cummings, Wim Annaert, Tom Cornelissen, Hans De Winter, Koen De Witte, Marc Fivaz, Gerard Griffioen
    Science . 2024 May 31
    PubMed
  • publication

    CORDAX web server: An online platform for the prediction and 3D visualization of aggregation motifs in protein sequences

    Nikolaos Louros, Frederic Rousseau, Joost Schymkowitz
    Bioinformatics . 2024 Apr 25
    PubMed
  • publication

    Mechanistic insights into the adaptive evolvability of spore heat resistance in Bacillus cereus sensu lato

    Sadhana Khanal, Tom Dongmin Kim, Katrien Begyn, Wouter Duverger, Gertjan Kramer, Stanley Brul, Andreja Rajkovic, Frank Devlieghere, Marc Heyndrickx, Joost Schymkowitz, Frederic Rousseau, Véronique Broussolle, Chris Michiels, Abram Aertsen
    Int J Food Microbiol . 2024 Apr 15
    PubMed
  • publication

    Integrating physics in deep learning algorithms: a force field as a PyTorch module

    Gabriele Orlando, Luis Serrano, Joost Schymkowitz, Frederic Rousseau
    Bioinformatics . 2024 Mar
    PubMed
  • publication

    CAGI, the Critical Assessment of Genome Interpretation, establishes progress and prospects for computational genetic variant interpretation methods

    CAGI community
    Genome Biol . 2024 Feb
    PubMed
  • publication

    Local structural preferences in shaping tau amyloid polymorphism

    Nikolaos Louros, Martin Wilkinson, Grigoria Tsaka, Meine Ramakers, Chiara Morelli, Teresa Garcia, Rodrigo Gallardo, Sam D'Haeyer, Vera Goossens, Dominique Audenaert, Dietmar Rudolf Thal, Ian R Mackenzie, Rosa Rademakers, Neil A Ranson, Sheena E Radford, Frederic Rousseau, Joost Schymkowitz
    Nat Commun . 2024 Feb 3
    PubMed