Welcome to the Switch Laboratory

Mapping aggregation-specific interactions in human disease

Our research focuses on understanding the mechanisms gearing protein folding and misfolding and their relation to human disease. In particular, we are investigating how protein aggregation affects the interactome by suppressing native interactions but also by introducing novel aggregation-specific interactions. These latter are especially relevant as they are usually associated with gain of function activities such as neurotoxicity (neurodegeneration).

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Newest publications

  • publication

    Sodium glutamate and glutamic acid decarboxylase as alternative for classical chemical leavening in wheat (pan)cake batter systems

    Elias Ravier, Thibault Godefroidt, Hung Huy Nguyen, Rob van der Kant, Elien Lemmens, Lomme J. Deleu, Kurt Gebruers, Joost Schymkowitz, Frederic Rousseau, Jan A. Delcour
    Journal of Cereal Science Volume 110, March 2023, 103638
  • publication

    Medin co-aggregates with vascular amyloid-β in Alzheimer's disease

    Jessica Wagner, Karoline Degenhardt, Marleen Veit, Nikolaos Louros, Katerina Konstantoulea, Angelos Skodras, Katleen Wild, Ping Liu, Ulrike Obermüller, Vikas Bansal, Anupriya Dalmia, Lisa M Häsler, Marius Lambert, Matthias De Vleeschouwer, Hannah A Davies, Jillian Madine, Deborah Kronenberg-Versteeg, Regina Feederle, Domenico Del Turco, K Peter R Nilsson, Tammaryn Lashley, Thomas Deller, Marla Gearing, Lary C Walker, Peter Heutink, Frederic Rousseau, Joost Schymkowitz, Mathias Jucker, Jonas J Neher
    Nature . 2022 Nov 16.
    PubMed
  • publication

    Seeding, maturation and propagation of amyloid β-peptide aggregates in Alzheimer's disease

    Xiaohang Li, Simona Ospitalieri, Tessa Robberechts, Linda Hofmann, Christina Schmid, Ajeet Rijal Upadhaya, Marta J Koper, , Christine A F von Arnim, Sathish Kumar, Michael Willem, Kathrin Gnoth, Meine Ramakers, Joost Schymkowitz, Frederic Rousseau, Jochen Walter, Alicja Ronisz, Karthikeyan Balakrishnan, Dietmar Rudolf Thal,
    Brain . 2022 Oct 21
    PubMed
  • publication

    De novo missense variants in the E3 ubiquitin ligase adaptor KLHL20 cause a developmental disorder with intellectual disability, epilepsy, and autism spectrum disorder

    Yoeri Sleyp, Irene Valenzuela, Andrea Accogli, Katleen Ballon, Bruria Ben-Zeev, Samuel F Berkovic, Martin Broly, Patrick Callaerts, Raymond C Caylor, Perrine Charles, Nicolas Chatron, Lior Cohen, Antonietta Coppola, Dawn Cordeiro, Claudia Cuccurullo, Ivon Cuscó, Janette diMonda, Ramon Duran-Romaña, Nina Ekhilevitch, Paula Fernández-Alvarez, Christopher T Gordon, Bertrand Isidor, Boris Keren, Gaetan Lesca, Jarymke Maljaars, Saadet Mercimek-Andrews, Michelle M Morrow, Alison M Muir, University of Washington Center for Mendelian Genomics; Frederic Rousseau, Vincenzo Salpietro, Ingrid E Scheffer, Rhonda E Schnur, Joost Schymkowitz, Erika Souche, Jean Steyaert, Elliot S Stolerman, Jaime Vengoechea, Dorothée Ville, Camerun Washington, Karin Weiss, Rinat Zaid, Lynette G Sadleir, Heather C Mefford, Hilde Peeters
    Genet Med. 2022 Oct 10
    PubMed
  • publication

    Exploiting ligand binding domain dimerization for development of novel androgen receptor inhibitors

    Christine Helsen, Tien Truong Nguyen, Xiao Yin Lee, Roy Eerlings, Nikolaos Louros, Joost Schymkowitz, Frederic Rousseau, Frank Claessens, Arnout Voet
    Mol Cancer Ther . 2022 Oct 11
    PubMed
  • publication

    Investigating the Sequence Determinants of the Curling of Amyloid Fibrils Using Ovalbumin as a Case Study

    Joëlle A J Housmans, Bert Houben, Margarita Monge-Morera, Diego Asvestas, Hung Huy Nguyen, Grigoria Tsaka, Nikolaos Louros, Sebastien Carpentier, Jan A Delcour, Frederic Rousseau, Joost Schymkowitz
    Biomacromolecules . 2022 Aug 26
    PubMed