Welcome to the Switch Laboratory

Mapping aggregation-specific interactions in human disease

Our research focuses on understanding the mechanisms gearing protein folding and misfolding and their relation to human disease. In particular, we are investigating how protein aggregation affects the interactome by suppressing native interactions but also by introducing novel aggregation-specific interactions. These latter are especially relevant as they are usually associated with gain of function activities such as neurotoxicity (neurodegeneration).

publication

Learn More about our Software

Discover more

Newest publications

  • publication

    A guide to studying protein aggregation

    Joëlle A J Housmans, Guiqin Wu, Joost Schymkowitz, Frederic Rousseau
    FEBS J . 2021 Dec 4
    PubMed
  • publication

    Heterotypic amyloid interactions: Clues to polymorphic bias and selective cellular vulnerability?

    Nikolaos Louros, Joost Schymkowitz, Frederic Rousseau
    Curr Opin Struct Biol . 2021 Dec 20
    PubMed
  • publication

    Heterotypic Amyloid β interactions facilitate amyloid assembly and modify amyloid structure

    Katerina Konstantoulea, Patricia Guerreiro, Meine Ramakers, Nikolaos Louros, Liam D Aubrey, Bert Houben, Emiel Michiels, Matthias De Vleeschouwer, Yulia Lampi, Luís F Ribeiro, Joris de Wit, Wei-Feng Xue, Joost Schymkowitz, Frederic Rousseau
    EMBO J . 2021 Nov 29
    PubMed
  • publication

    Highly efficient intercellular spreading of protein misfolding mediated by viral ligand-receptor interactions

    Shu Liu, André Hossinger, Stefanie-Elisabeth Heumüller, Annika Hornberger, Oleksandra Buravlova, Katerina Konstantoulea, Stephan A Müller, Lydia Paulsen, Frederic Rousseau, Joost Schymkowitz, Stefan F Lichtenthaler, Manuela Neumann, Philip Denner, Ina M Vorberg
    Nat Commun . 2021 Oct 19
    PubMed
  • publication

    Bcl-xL acts as an inhibitor of IP 3 R channels, thereby antagonizing Ca 2+-driven apoptosis

    Nicolas Rosa, Hristina Ivanova , Larry E Wagner 2nd, Justin Kale, Rita La Rovere, Kirsten Welkenhuyzen, Nikolaos Louros, Spyridoula Karamanou, Victoria Shabardina, Irma Lemmens, Elien Vandermarliere, Kozo Hamada , Hideaki Ando, Frederic Rousseau, Joost Schymkowitz, Jan Tavernier, Katsuhiko Mikoshiba, Anastassios Economou, David W Andrews, Jan B Parys, David I Yule, Geert Bultynck
    Cell Death Differ . 2021 Nov 8
    PubMed
  • publication

    The cellular modifier MOAG-4/SERF drives amyloid formation through charge complementation

    Anita Pras, Bert Houben, Francesco A Aprile, Renée Seinstra, Rodrigo Gallardo, Leen Janssen, Wytse Hogewerf, Christian Gallrein, Matthias De Vleeschouwer, Alejandro Mata-Cabana, Mandy Koopman, Esther Stroo, Minke de Vries, Samantha Louise Edwards, Janine Kirstein, Michele Vendruscolo, Salvatore Fabio Falsone, Frederic Rousseau, Joost Schymkowitz, Ellen A A Nollen
    EMBO J . 2021 Oct 7;e107568
    PubMed