Mapping aggregation-specific interactions in human disease

Newest publications

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  Mimicking the structure and function of tau folds associated with disease

  Joost Schymkowitz & Frederic Rousseau

  Nat Chem . 2025 May 23

  PubMed
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  Directed disruption of IL2 aggregation and receptor binding sites produces designer biologics with enhanced specificity and improved production capacity

  Amy Dashwood, Ntombizodwa Makuyana, Rob van der Kant, Arman Ghodsinia, Alvaro R Hernandez, Stephanie Lienart, Oliver Burton, James Dooley, Magda Ali, Lubna Kouser, Francisco Naranjo, Matthew G Holt, Frederic Rousseau, Joost Schymkowitz, Adrian Liston

  Comput Struct Biotechnol J . 2025 Mar

  PubMed
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  Charting the structure-sequence landscape of light chain amyloids

  Gabriele Orlando, Rodrigo Gallardo, Alicia Colla, Joost Schymkowitz, Frederic Rousseau

  Bioinformatics 2025 Apr

  PubMed
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  TDP-43 seeding induces cytoplasmic aggregation heterogeneity and nuclear loss of function of TDP-43

  Jens Rummens, Bilal Khalil, Günseli Yıldırım, Pedro Silva, Valentina Zorzini, Nicolas Peredo, Marta Wojno, Meine Ramakers, Ludo Van Den Bosc, Philip Van Damme, Kristofer Davie, Jelle Hendrix, Frederic Rousseau 7, Joost Schymkowitz, Sandrine Da Cruz

  Neuron 2025 Mar 26

  PubMed
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  Impact of amyloid-like ovalbumin fibril consumption on health-related markers: An in vitro approach

  Trui Luyckx, Charlotte Grootaert, Jan A. Delcour, Joëlle A.J. Housmans, Frederic Rousseau, Joost Schymkowitz, Sebastien Carpentier, John Van Camp

  Food Research International vol 208

  PubMed
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  Development and evaluation of Hsp90-targeting nanobodies for visualisation of extracellular Hsp90 in tumours using PET imaging

  Valeria Narykina, Janke Kleynhans, Christopher Cawthorne, Joost Schymkowitz, Frederic Rousseau, Guy Bormans

  EJNMMI Radiopharm Chem . 2025 Feb 21

  PubMed