Mapping aggregation-specific interactions in human disease

Newest publications

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  Impact of heat and enzymatic treatment on ovalbumin amyloid-like fibril formation and enzyme-induced gelation

  Huyst, AMR; Deleu, LJ; Luyckx, T; Meeren, LV; Housmans, JAJ; Grootaert, C; Monge-Morera, M; Delcour, JA; Skirtach, AG; Rousseau, F; Schymkowitz, J; Dewettinck, K; van der Meeren, P

  FOOD HYDROCOLLOIDS

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  HPMPdb: A machine learning-ready database of protein molecular phenotypes associated to human missense variants

  Daniele Raimondi, Francesco Codicè, Gabriele Orlando, Joost Schymkowitz, Frederic Rousseau, Yves Moreau

  Curr Res Struct Biol . 2022 May 13

  PubMed
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  The effect of mutation on an aggregation-prone protein: An in vivo, in vitro, and in silico analysis

  N Guthertz, R van der Kant, R M Martinez, Y Xu, C Trinh, B I Iorga, F Rousseau, J Schymkowitz, D J Brockwell, S E Radford

  Proc Natl Acad Sci U S A . 2022 May 31

  PubMed
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  Thermodynamic analysis of amyloid fibril structures reveals a common framework for stability in amyloid polymorphs

  Rob van der Kant, Nikolaos Louros, Joost Schymkowitz, Frederic Rousseau

  Structure . 2022 May 15

  PubMed
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  Mapping the sequence specificity of heterotypic amyloid interactions enables the identification of aggregation modifiers

  Nikolaos Louros, Meine Ramakers, Emiel Michiels, Katerina Konstantoulea, Chiara Morelli, Teresa Garcia, Nele Moonen, Sam D'Haeyer, Vera Goossens, Dietmar Rudolf Thal, Dominique Audenaert, Frederic Rousseau, Joost Schymkowitz

  Nat Commun . 2022 Mar 15

  PubMed
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  StAmP-DB: A platform for structures of polymorphic amyloid fibril cores

  Nikolaos Louros, Rob van der Kant, Joost Schymkowitz, Frederic Rousseau

  Bioinformatics . 2022 Feb 23

  PubMed