Welcome to the Switch Laboratory

Mapping aggregation-specific interactions in human disease

Our research focuses on understanding the mechanisms gearing protein folding and misfolding and their relation to human disease. In particular, we are investigating how protein aggregation affects the interactome by suppressing native interactions but also by introducing novel aggregation-specific interactions. These latter are especially relevant as they are usually associated with gain of function activities such as neurotoxicity (neurodegeneration).


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Newest publications

  • publication

    TDP-43 pathology is associated with increased tau burdens and seeding

    Sandra O Tomé, Grigoria Tsaka, Alicja Ronisz, Simona Ospitalieri, Klara Gawor, Luis Aragão Gomes, Markus Otto, Christine A F von Arnim, Philip Van Damme, Ludo Van Den Bosch, Estifanos Ghebremedhin, Celeste Laureyssen, Kristel Sleegers, Rik Vandenberghe, Frederic Rousseau , Joost Schymkowitz, Dietmar Rudolf Thal
    Mol Neurodegener . 2023 Sep 30
  • publication

    Exploiting the aggregation propensity of beta-lactamases to design inhibitors that induce enzyme misfolding

    Ladan Khodaparast, Laleh Khodaparast, Guiqin Wu, Emiel Michiels, Rodrigo Gallardo, Bert Houben, Teresa Garcia, Matthias De Vleeschouwer, Meine Ramakers, Hannah Wilkinson, Ramon Duran-Romaña, Johan Van Eldere , Frederic Rousseau, Joost Schymkowitz
    Nat Commun Sept 2023
  • publication

    Mechanisms and pathology of protein misfolding and aggregation

    Nikolaos Louros, Joost Schymkowitz, Frederic Rousseau
    Nat Rev Mol Cell Biol
  • publication

    Modulation of hen egg white protein techno-functionality by amyloid formation

    Margarita Monge-Morera, Nele Vluymans, Joëlle A.J. Housmans, Anja Vananroye, Paula Moldenaers, Joost Schymkowitz, Frederic Rousseau, Jan A. Delcour
    Food Hydrocolloids Volume 146, Part A
  • publication

    Improved coalescence and creaming stability of structured oil-in-water emulsions and emulsion gels containing ovalbumin amyloid-like fibrils produced by heat and enzymatic treatments

    Arne M.R. Huyst, Paul Van der Meeren, Joëlle A.J. Housmans, Margarita Monge-Morera, Frederic Rousseau, Joost Schymkowitz, Jan A. Delcour
    Food Hydrocolloids
  • publication

    SNPeffect 5.0: large-scale structural phenotyping of protein coding variants extracted from next-generation sequencing data using AlphaFold models

    Kobe Janssen , Ramon Duran-Romaña, Guy Bottu, Mainak Guharoy, Alexander Botzki , Frederic Rousseau, Joost Schymkowitz
    BMC Bioinformatics . 2023 Jul 18