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    Highly efficient intercellular spreading of protein misfolding mediated by viral ligand-receptor interactions

    Shu Liu, André Hossinger, Stefanie-Elisabeth Heumüller, Annika Hornberger, Oleksandra Buravlova, Katerina Konstantoulea, Stephan A Müller, Lydia Paulsen, Frederic Rousseau, Joost Schymkowitz, Stefan F Lichtenthaler, Manuela Neumann, Philip Denner, Ina M Vorberg
    Nat Commun . 2021 Oct 19
    PubMed
  • publication

    Bcl-xL acts as an inhibitor of IP 3 R channels, thereby antagonizing Ca 2+-driven apoptosis

    Nicolas Rosa, Hristina Ivanova , Larry E Wagner 2nd, Justin Kale, Rita La Rovere, Kirsten Welkenhuyzen, Nikolaos Louros, Spyridoula Karamanou, Victoria Shabardina, Irma Lemmens, Elien Vandermarliere, Kozo Hamada , Hideaki Ando, Frederic Rousseau, Joost Schymkowitz, Jan Tavernier, Katsuhiko Mikoshiba, Anastassios Economou, David W Andrews, Jan B Parys, David I Yule, Geert Bultynck
    Cell Death Differ . 2021 Nov 8
    PubMed
  • publication

    The cellular modifier MOAG-4/SERF drives amyloid formation through charge complementation

    Anita Pras, Bert Houben, Francesco A Aprile, Renée Seinstra, Rodrigo Gallardo, Leen Janssen, Wytse Hogewerf, Christian Gallrein, Matthias De Vleeschouwer, Alejandro Mata-Cabana, Mandy Koopman, Esther Stroo, Minke de Vries, Samantha Louise Edwards, Janine Kirstein, Michele Vendruscolo, Salvatore Fabio Falsone, Frederic Rousseau, Joost Schymkowitz, Ellen A A Nollen
    EMBO J . 2021 Oct 7;e107568
    PubMed
  • publication

    Protein structure and aggregation: a marriage of necessity ruled by aggregation gatekeepers

    Bert Houben, Frederic Rousseau, Joost Schymkowitz
    Trends Biochem Sci . 2021 Sep
    PubMed
  • publication

    Synthetic Pept-Ins as a Generic Amyloid-Like Aggregation-Based Platform for In Vivo PET Imaging of Intracellular Targets

    Maxime Siemons, Kaat Luyten, Ladan Khodaparast, Laleh Khodaparast, Joan Lecina, Filip Claes, Rodrigo Gallardo, Michel Koole, Meine Ramakers, Joost Schymkowitz, Guy Bormans, Frederic Rousseau
    Bioconjug Chem . 2021 Sep 15
    PubMed
  • publication

    The Dynamic Transition of Persistence toward the Viable but Nonculturable State during Stationary Phase Is Driven by Protein Aggregation

    Liselot Dewachter, Celien Bollen, Dorien Wilmaerts, Elen Louwagie, Pauline Herpels, Paul Matthay, Ladan Khodaparast, Laleh Khodaparast, Frederic Rousseau, Joost Schymkowitz, Jan Michiels
    mBio . 2021 Aug 3
    PubMed