Welcome to the Switch Laboratory

Mapping aggregation-specific interactions in human disease

Our research focuses on understanding the mechanisms gearing protein folding and misfolding and their relation to human disease. In particular, we are investigating how protein aggregation affects the interactome by suppressing native interactions but also by introducing novel aggregation-specific interactions. These latter are especially relevant as they are usually associated with gain of function activities such as neurotoxicity (neurodegeneration).

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Newest publications

  • publication

    The sweet spot in protein design-Where deep learning meets first principles

    Gabriel Cia, Gabriele Orlando, Damiano Cianferoni, Rob van der Kant, Javier Delgado Blanco, Erik Verschueren, Frederic Rousseau, Luis Serrano, Joost Schymkowitz
    FEBS Lett . 2026 Aug 10.
    PubMed
  • publication

    Proteomic profiling of whole tissue sections in cardiac ATTR amyloidosis reveals increased extracellular matrix remodeling

    Annelore Vandendriessche, Teresa M Maia, Frank Timmermans, Delphi Van Haver, Sara Dufour, An Staes, Joost Schymkowitz, Frederic Rousseau, Rodrigo Gallardo, Michel Delforge, Jo Van Dorpe, Simon Devos, Francis Impens, Amélie Dendooven
    Cardiovasc Pathol . 2026 Jun 16
    PubMed
  • publication

    Confirmation of monotypic immunofluorescence staining by mass spectrometry in a case of proliferative glomerulonephritis

    Lyssa Van De Ginste, Annelore Vandendriessche, An S De Vriese, Jack Wetzels, Steven Van Laecke, Tri Q Nguyen, Michel Delforge, Rodrigo Gallardo, Joost Schymkowitz, Frédéric Rousseau, Francis Impens, Simon Devos, Amélie Dendooven
    Histopathology . 2026 May 13
    PubMed
  • publication

    FoldDelay web server: an online tool to quantify translation-driven delays in protein native contact formation

    Ramon Duran‑Romaña, Joost Schymkowitz, Frederic Rousseau
    Nucleic Acids Res . 2026 Apr 28
    PubMed
  • publication

    Atomic structures of medin and Aβ fibrils reveal polymorphic remodeling in mixed amyloid systems

    Brajabandhu Pradhan, Senthil T Kumar, Jessica Wagner, Rodrigo Gallardo, Gabriele Orlando, Matthias De Vleeschouwer, Valentina Zorzini, Jillian Madine, Nikolaos Louros, Jonas J Neher, Frederic Rousseau, Joost Schymkowitz
    Nat Commun . 2026 Apr 28.
    PubMed
  • publication

    Belgian recommendations for tissue diagnosis of amyloidosis

    Amélie Dendooven, Annelore Vandendriessche, Priyanka Joseph Koshy, Frank Timmermans, Marijn Speeckaert, Nicolas Kint, Lucas Van Aelst, Marie‑Christiane Vekemans, Nathalie Meuleman, Anne‑Catherine Pouleur, Antoine Bondue, Steven Droogmans, Philippe Debonnaire, Jan De Bleecker, Amaryllis Van Craenenbroeck, Rodrigo Gallardo, Joost Schymkowitz, Frédéric Rousseau, Francis Impens, Simon Devos, Michel Delforge
    Acta Clin Belg . 2026
    PubMed