Mapping aggregation-specific interactions in human disease

Newest publications

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  Structure-based machine-guided mapping of amyloid sequence space reveals uncharted sequence clusters with higher solubilities

  Nikolaos Louros, Gabriele Orlando, Matthias De Vleeschouwer, Frederic Rousseau, Joost Schymkowitz

  Nat Commun

  PubMed
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  Processing Induced Changes in Food Proteins: Amyloid Formation During Boiling of Hen Egg White

  Margarita Monge-Morera, Marlies A Lambrecht, Lomme J Deleu, Rodrigo Gallardo, Nikolaos N Louros, Matthias De Vleeschouwer, Frederic Rousseau, Joost Schymkowitz, Jan A Delcour

  Biomacromolecules 2020 Mar 23

  PubMed
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  Thermodynamic and Evolutionary Coupling Between the Native and Amyloid State of Globular Proteins

  Tobias Langenberg, Rodrigo Gallardo, Rob van der Kant, Nikolaos Louros , Emiel Michiels, Ramon Duran-Romaña, Bert Houben, Rafaela Cassio, Hannah Wilkinson, Teresa Garcia, Chris Ulens, Joost Van Durme, Frederic Rousseau, Joost Schymkowitz

  Cell Rep . 2020 Apr 14;31(2):107512

  PubMed
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  Entropic Bristles Tune the Seeding Efficiency of Prion-Nucleating Fragments.

  Michiels E, Liu S, Gallardo R, Louros N, Mathelié-Guinlet M, Dufrêne Y, Schymkowitz J, Vorberg I, Rousseau F

  Cell Rep. 2020 Feb 25;30(8):2834-2845.e3

  PubMed
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  Defective SEC61α1 Underlies a Novel Cause of Autosomal Dominant Severe Congenital Neutropenia

  Erika Van Nieuwenhove, John S Barber, Julika Neumann, Elien Smeets 3, Mathijs Willemsen 2, Emanuela Pasciuto 2, Teresa Prezzemolo 2, Vasiliki Lagou 2, Laura Seldeslachts 4, Bert Malengier-Devlies 5, Mieke Metzemaekers 6, Sarah Haßdenteufel 7, Axelle Kerstens 8, Rob van der Kant 9, Frederic Rousseau 9, Joost Schymkowitz 9, Daniele Di Marino , Sven Lang, Richard Zimmermann, Susan Schlenner, Sebastian Munck, Paul Proost, Patrick Matthys, Christine Devalck, Nancy Boeckx, Frank Claessens, Carine Wouters, Stephanie Humblet-Baron, Isabelle Meyts, Adrian Liston

  J Allergy Clin Immunol . 2020 Apr 20;S0091-6749(20)30488-7

  PubMed
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  Preparation of Amorphous Solid Dispersions by Cryomilling: Chemical and Physical Concerns Related to Active Pharmaceutical Ingredients and Carriers

  Pas T, Bergonzi A, Michiels E, Rousseau F, Schymkowitz J, Koekoekx R, Clasen C, Vergauwen B, Van den Mooter G

  Mol Pharm. 2020 Feb 12. doi: 10.1021

  PubMed