Welcome to the Switch Laboratory

Mapping aggregation-specific interactions in human disease

Our research focuses on understanding the mechanisms gearing protein folding and misfolding and their relation to human disease. In particular, we are investigating how protein aggregation affects the interactome by suppressing native interactions but also by introducing novel aggregation-specific interactions. These latter are especially relevant as they are usually associated with gain of function activities such as neurotoxicity (neurodegeneration).

publication

Learn More about our Software

Discover more

Newest publications

  • publication

    Thermodynamic analysis of amyloid fibril structures reveals a common framework for stability in amyloid polymorphs

    Rob van der Kant, Nikolaos Louros, Joost Schymkowitz, Frederic Rousseau
    Structure . 2022 May 15
    PubMed
  • publication

    Mapping the sequence specificity of heterotypic amyloid interactions enables the identification of aggregation modifiers

    Nikolaos Louros, Meine Ramakers, Emiel Michiels, Katerina Konstantoulea, Chiara Morelli, Teresa Garcia, Nele Moonen, Sam D'Haeyer, Vera Goossens, Dietmar Rudolf Thal, Dominique Audenaert, Frederic Rousseau, Joost Schymkowitz
    Nat Commun . 2022 Mar 15
    PubMed
  • publication

    StAmP-DB: A platform for structures of polymorphic amyloid fibril cores

    Nikolaos Louros, Rob van der Kant, Joost Schymkowitz, Frederic Rousseau
    Bioinformatics . 2022 Feb 23
    PubMed
  • publication

    Bioavailability and Health Impact of Ingested Amyloid-like Protein Fibrils and their Link with Inflammatory Status: a Need for More Research?

    Trui Luyckx, Charlotte Grootaert, Margarita Monge-Morera, Jan A Delcour, Frederic Rousseau, Joost Schymkowitz, John Van Camp
    Mol Nutr Food Res . 2022 Feb
    PubMed
  • publication

    PyUUL provides an interface between biological structures and deep learning algorithms

    Gabriele Orlando, Daniele Raimondi, Ramon Duran-Romaña, Yves Moreau, Joost Schymkowitz, Frederic Rousseau
    Nat Commun . 2022 Feb 18
    PubMed
  • publication

    A guide to studying protein aggregation

    Joëlle A J Housmans, Guiqin Wu, Joost Schymkowitz, Frederic Rousseau
    FEBS J . 2021 Dec 4
    PubMed