Mapping aggregation-specific interactions in human disease

Newest publications

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  Reduced Levels of Misfolded and Aggregated Mutant p53 by Proteostatic Activation

  Evelyne Naus, Marleen Derweduwe, Youlia Lampi, Annelies Claeys, Jarne Pauwels, Tobias Langenberg, Filip Claes, Jie Xu, Veerle Haemels, Zeynep Kalender Atak, Rob van der Kant, Joost Van Durme, Greet De Baets, Keith L Ligon, Mark Fiers, Kris Gevaert, Stein Aerts, Frederic Rousseau, Joost Schymkowitz, Frederik De Smet

  Cells . 2023 Mar 21

  PubMed10.3390/cells12060960
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  EndophilinA-dependent coupling between activity-induced calcium influx and synaptic autophagy is disrupted by a Parkinson-risk mutation

  Adekunle T Bademosi, Marianna Decet, Sabine Kuenen, Carles Calatayud, Jef Swerts, Sandra F Gallego, Nils Schoovaerts, Spyridoula Karamanou, Nikolaos Louros, Ella Martin, Jean-Baptiste Sibarita, Katlijn Vints, Natalia V Gounko, Frédéric A Meunier, Anastassios Economou, Wim Versées, Frederic Rousseau, Joost Schymkowitz, Sandra-F Soukup, Patrik Verstreken

  Neuron . 2023 Feb 15

  PubMed10.1016/j.neuron.2023.02.001.
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  Exploiting the intrinsic misfolding propensity of the KRAS oncoprotein

  Kobe Janssen, Filip Claes, Dido Van de Velde, Vanessa L Wehbi, Bert Houben, Yulia Lampi, Mieke Nys, Laleh Khodaparast, Ladan Khodaparast, Nikolaos Louros, Rob van der Kant, Joffre Verniers, Teresa Garcia, Meine Ramakers, Katerina Konstantoulea, Katerina Maragkou, Ramon Duran-Romaña, Mónica Musteanu, Mariano Barbacid, Bernard Scorneaux, Els Beirnaert, Joost Schymkowitz, Frederic Rousseau

  Proc Natl Acad Sci U S A . 2023 Feb 28

  PubMed10.1073/pnas.2214921120
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  Sodium glutamate and glutamic acid decarboxylase as alternative for classical chemical leavening in wheat (pan)cake batter systems

  Elias Ravier, Thibault Godefroidt, Hung Huy Nguyen, Rob van der Kant, Elien Lemmens, Lomme J. Deleu, Kurt Gebruers, Joost Schymkowitz, Frederic Rousseau, Jan A. Delcour

  Journal of Cereal Science Volume 110, March 2023, 103638

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  Medin co-aggregates with vascular amyloid-β in Alzheimer's disease

  Jessica Wagner, Karoline Degenhardt, Marleen Veit, Nikolaos Louros, Katerina Konstantoulea, Angelos Skodras, Katleen Wild, Ping Liu, Ulrike Obermüller, Vikas Bansal, Anupriya Dalmia, Lisa M Häsler, Marius Lambert, Matthias De Vleeschouwer, Hannah A Davies, Jillian Madine, Deborah Kronenberg-Versteeg, Regina Feederle, Domenico Del Turco, K Peter R Nilsson, Tammaryn Lashley, Thomas Deller, Marla Gearing, Lary C Walker, Peter Heutink, Frederic Rousseau, Joost Schymkowitz, Mathias Jucker, Jonas J Neher

  Nature . 2022 Nov 16.

  PubMed
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  Seeding, maturation and propagation of amyloid β-peptide aggregates in Alzheimer's disease

  Xiaohang Li, Simona Ospitalieri, Tessa Robberechts, Linda Hofmann, Christina Schmid, Ajeet Rijal Upadhaya, Marta J Koper, , Christine A F von Arnim, Sathish Kumar, Michael Willem, Kathrin Gnoth, Meine Ramakers, Joost Schymkowitz, Frederic Rousseau, Jochen Walter, Alicja Ronisz, Karthikeyan Balakrishnan, Dietmar Rudolf Thal,

  Brain . 2022 Oct 21

  PubMed