Mapping aggregation-specific interactions in human disease

Newest publications

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  Potential human transmission of amyloid β pathology: surveillance and risks

  Elsa Lauwers, Giovanna Lalli, Sebastian Brandner, John Collinge, Veerle Compernolle, Charles Duyckaerts, Gustaf Edgren, Stéphane Haïk, John Hardy, Adel Helmy , Adrian J Ivinson, Zane Jaunmuktane , Mathias Jucker, Richard Knight, Robin Lemmens, I-Chun Lin, Seth Love, Simon Mead, V Hugh Perry, James Pickett, Guy Poppy, Sheena E Radford, Frederic Rousseau, Carol Routledge, Giampietro Schiavo, Joost Schymkowitz, Dennis J Selkoe, Colin Smith, Dietmar R Thal, Tom Theys, Pierre Tiberghien, Peter van den Burg, Philippe Vandekerckhove, Clare Walton, Hans L Zaaijer, Henrik Zetterberg, Bart De Strooper

  Review Lancet Neurol

  PubMed
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  Structure-based machine-guided mapping of amyloid sequence space reveals uncharted sequence clusters with higher solubilities

  Nikolaos Louros, Gabriele Orlando, Matthias De Vleeschouwer, Frederic Rousseau, Joost Schymkowitz

  Nature Communications 11 (1):3314.

  PubMed
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  Processing Induced Changes in Food Proteins: Amyloid Formation During Boiling of Hen Egg White

  Margarita Monge-Morera, Marlies A Lambrecht, Lomme J Deleu, Rodrigo Gallardo, Nikolaos N Louros, Matthias De Vleeschouwer, Frederic Rousseau, Joost Schymkowitz, Jan A Delcour

  Biomacromolecules 21 (6):2218-2228.

  PubMed
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  Reverse Engineering Synthetic Antiviral Amyloids

  Emiel Michiels, Kenny Roose, Rodrigo Gallardo, Ladan Khodaparast, Laleh Khodaparast, Rob van der Kant, Maxime Siemons, Bert Houben, Meine Ramakers, Hannah Wilkinson, Patricia Guerreiro, Nikolaos Louros, Suzanne J F Kaptein, Lorena Itatí Ibañez, Anouk Smet, Pieter Baatsen, Shu Liu, Ina Vorberg, Guy Bormans, Johan Neyts , Xavier Saelens, Frederic Rousseau, Joost Schymkowitz

  Nat Commun. 2020 Jun 5;11(1):2832.

  PubMed
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  Autonomous Aggregation Suppression by Acidic Residues Explains Why Chaperones Favour Basic Residues

  Bert Houben, Emiel Michiels, Meine Ramakers, Katerina Konstantoulea, Nikolaos Louros, Joffré Verniers, Rob van der Kant, Matthias De Vleeschouwer, Nuno Chicória, Thomas Vanpoucke, Rodrigo Gallardo, Joost Schymkowitz, Frederic Rousseau

  EMBO J 39 (11):e102864

  PubMed
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  Defective SEC61α1 Underlies a Novel Cause of Autosomal Dominant Severe Congenital Neutropenia

  Erika Van Nieuwenhove, John S Barber, Julika Neumann, Elien Smeets 3, Mathijs Willemsen 2, Emanuela Pasciuto 2, Teresa Prezzemolo 2, Vasiliki Lagou 2, Laura Seldeslachts 4, Bert Malengier-Devlies 5, Mieke Metzemaekers 6, Sarah Haßdenteufel 7, Axelle Kerstens 8, Rob van der Kant 9, Frederic Rousseau 9, Joost Schymkowitz 9, Daniele Di Marino , Sven Lang, Richard Zimmermann, Susan Schlenner, Sebastian Munck, Paul Proost, Patrick Matthys, Christine Devalck, Nancy Boeckx, Frank Claessens, Carine Wouters, Stephanie Humblet-Baron, Isabelle Meyts, Adrian Liston

  J Allergy Clin Immunol . 2020 Apr 20;S0091-6749(20)30488-7

  PubMed