Post Doc - Cellular biology of heterotypic amyloid interactions
We are looking for a highly skilled postdoctoral researcher with strong expertise in cell biology to join our NIH-funded project, which focuses on identifying and characterizing heterotypic amyloid interactions as modulators of selective cellular vulnerability. As the project progresses, we are entering a crucial phase that involves detailed cellular assays to explore and validate the roles of these interactions. Your expertise will be key in driving this exciting research forward and exploring the implications of these interactions in cellular systems.
What is the project all about?
Amyloid aggregates manifest in specific brain regions while sparing others. Our project aims to unravel whether heterotypic interactions between aggregation-prone regions of amyloid-forming proteins and the background proteome dictate this selective vulnerability. This hypothesis will be tested using a genome-wide computational screen, followed by experimental validation in cellular models and, subsequently, in mice. A key aspect of this research will involve cell biological techniques to validate interactions and elucidate how these alter cellular functions and drive disease processes
The job
As a key member of our ‘heterotypics’ team, you will be at the forefront of this project, integrating your expertise in cellular biology with protein aggregation research. Working closely with the PIs of the Switch Lab, this role offers a mix of hands-on experimental work and data analysis, with robust administrative support to ensure you can focus on driving scientific discovery.
Your profile
- PhD with strong focus on Cell Biology, ideally in the setting of protein aggregation, protein homeostasis, or a related field.
- Extensive experience with cellular models and assays related to protein aggregation, including microscopy, cell-based screening, and related techniques.
- A strong interest in understanding the cellular mechanisms underlying protein aggregation and its implications in disease.
- A solid publication record with first-author research publication(s) in peer-reviewed international journals
- Highly motivated, enthusiastic and innovative, with excellent communication skills
- Prior supervisory or project coordination experience is a plus
- The ability to work in a multidisciplinary team
We offer
- A vibrant, world-class research environment operating at an international level
- A dedicated training program to broaden your expertise and enhance your skillset.
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Access to the resources of two host institutions:
- A competitive compensation package based on expertise and experience.
At SWITCH we have particular attention for the career development goals of our people and actively support the ambitions of our lab members in the lab and beyond. Information on SWITCH Lab alumni can be found here.
How to apply
For more information contact us. To apply, please complete the online application procedure
