Post Doc - Cellular biology of heterotypic amyloid interactions

We recently secured NIH funding for a project investigating heterotypic amyloid interactions as modulators of selective cellular vulnerability. We’re looking for an experienced postdoctoral researcher with a strong background in cell biology within a protein aggregation context.

What is the project all about?

Amyloid aggregates form in certain regions of the brain and not in others. We will investigate whether specific (heterotypic) interactions between the aggregation-prone regions of amyloid-forming proteins and the background proteome account for this. This hypothesis will be tested by performing a genome-wide computational screen and then testing the candidate proteins first in cellular models and then in mice. Biophysical analyses will shine a light on the exact mechanism by which heterotypic interactions change amyloid formation.

The job

Together with the PIs of the Switch Lab you will be part of a team of post docs and technicians and will be a driving force for this project. You will be well supported on an administrative level, allowing you to focus on the science, both hands-on in the lab and analyzing data.

Your profile

• PhD in a topic related to protein aggregation or protein homeostasis • Expertise in cellular biology of protein aggregation and related assays • Strong interest in protein aggregation and its role in disease. • A solid publication record with first-author research publication(s) in peer-reviewed international journals • Highly motivated, enthusiastic, critical and creative • Written and oral communication skills of the highest level • The ability to work in a multidisciplinary team • Prior supervisory or project coordination experience is a plus

We offer

• A vibrant, world-class research environment operating at an international level
• A dedicated training program to broaden your expertise and enhance your skillset.

• Access to the resources of two host institutions:

  • VIB, an excellence-based research institute
  • KU Leuven, one of Europe’s leading research universities.
• A competitive compensation package based on expertise and experience.

At SWITCH we have particular attention for the career development goals of our people and actively support the ambitions of our lab members in the lab and beyond. Information on SWITCH Lab alumni can be found here.

How to apply

For more information contact us. To apply, please complete the online application procedure