Louros N, et al. Nature Communications 13 (1):1351, 2022
In this paper, Nikos Louros mapped the sequence specificity of heterotypic amyloid interactions of tau to discover the rules of how tau amyloid aggregates engage with other proteins. Knowing these rules allowed identifying aggregation modifier proteins that promote tau fibril formation in cells (a mechanism that could potentially explain selective vulnerability to amyloid aggregates in neurodegenerative disorders) and selective and highly potent amyloid-inhibitors.
Read the full paper here (open access)
Read Nikos’ post on LinkedIn here.