Reduced Levels of Misfolded and Aggregated Mutant p53 by Proteostatic Activation
Evelyne Naus, Marleen Derweduwe, Youlia Lampi, Annelies Claeys, Jarne Pauwels, Tobias Langenberg, Filip Claes, Jie Xu, Veerle Haemels, Zeynep Kalender Atak, Rob van der Kant, Joost Van Durme, Greet De Baets, Keith L Ligon, Mark Fiers, Kris Gevaert, Stein Aerts, Frederic Rousseau, Joost Schymkowitz, Frederik De Smet
Sodium glutamate and glutamic acid decarboxylase as alternative for classical chemical leavening in wheat (pan)cake batter systems
Elias Ravier, Thibault Godefroidt, Hung Huy Nguyen, Rob van der Kant, Elien Lemmens, Lomme J. Deleu, Kurt Gebruers, Joost Schymkowitz, Frederic Rousseau, Jan A. Delcour
Journal of Cereal Science Volume 110, March 2023, 103638
2022
Medin co-aggregates with vascular amyloid-β in Alzheimer's disease
Jessica Wagner, Karoline Degenhardt, Marleen Veit, Nikolaos Louros, Katerina Konstantoulea, Angelos Skodras, Katleen Wild, Ping Liu, Ulrike Obermüller, Vikas Bansal, Anupriya Dalmia, Lisa M Häsler, Marius Lambert, Matthias De Vleeschouwer, Hannah A Davies, Jillian Madine, Deborah Kronenberg-Versteeg, Regina Feederle, Domenico Del Turco, K Peter R Nilsson, Tammaryn Lashley, Thomas Deller, Marla Gearing, Lary C Walker, Peter Heutink, Frederic Rousseau, Joost Schymkowitz, Mathias Jucker, Jonas J Neher
De novo missense variants in the E3 ubiquitin ligase adaptor KLHL20 cause a developmental disorder with intellectual disability, epilepsy, and autism spectrum disorder
Yoeri Sleyp, Irene Valenzuela, Andrea Accogli, Katleen Ballon, Bruria Ben-Zeev, Samuel F Berkovic, Martin Broly, Patrick Callaerts, Raymond C Caylor, Perrine Charles, Nicolas Chatron, Lior Cohen, Antonietta Coppola, Dawn Cordeiro, Claudia Cuccurullo, Ivon Cuscó, Janette diMonda, Ramon Duran-Romaña, Nina Ekhilevitch, Paula Fernández-Alvarez, Christopher T Gordon, Bertrand Isidor, Boris Keren, Gaetan Lesca, Jarymke Maljaars, Saadet Mercimek-Andrews, Michelle M Morrow, Alison M Muir, University of Washington Center for Mendelian Genomics; Frederic Rousseau, Vincenzo Salpietro, Ingrid E Scheffer, Rhonda E Schnur, Joost Schymkowitz, Erika Souche, Jean Steyaert, Elliot S Stolerman, Jaime Vengoechea, Dorothée Ville, Camerun Washington, Karin Weiss, Rinat Zaid, Lynette G Sadleir, Heather C Mefford, Hilde Peeters
Highly efficient intercellular spreading of protein misfolding mediated by viral ligand-receptor interactions
Shu Liu, André Hossinger, Stefanie-Elisabeth Heumüller, Annika Hornberger, Oleksandra Buravlova, Katerina Konstantoulea, Stephan A Müller, Lydia Paulsen, Frederic Rousseau, Joost Schymkowitz, Stefan F Lichtenthaler, Manuela Neumann, Philip Denner, Ina M Vorberg
Bcl-xL acts as an inhibitor of IP 3 R channels, thereby antagonizing Ca 2+-driven apoptosis
Nicolas Rosa, Hristina Ivanova , Larry E Wagner 2nd, Justin Kale, Rita La Rovere, Kirsten Welkenhuyzen, Nikolaos Louros, Spyridoula Karamanou, Victoria Shabardina, Irma Lemmens, Elien Vandermarliere, Kozo Hamada , Hideaki Ando, Frederic Rousseau, Joost Schymkowitz, Jan Tavernier, Katsuhiko Mikoshiba, Anastassios Economou, David W Andrews, Jan B Parys, David I Yule, Geert Bultynck
The cellular modifier MOAG-4/SERF drives amyloid formation through charge complementation
Anita Pras, Bert Houben, Francesco A Aprile, Renée Seinstra, Rodrigo Gallardo, Leen Janssen, Wytse Hogewerf, Christian Gallrein, Matthias De Vleeschouwer, Alejandro Mata-Cabana, Mandy Koopman, Esther Stroo, Minke de Vries, Samantha Louise Edwards, Janine Kirstein, Michele Vendruscolo, Salvatore Fabio Falsone, Frederic Rousseau, Joost Schymkowitz, Ellen A A Nollen
Synthetic Pept-Ins as a Generic Amyloid-Like Aggregation-Based Platform for In Vivo PET Imaging of Intracellular Targets
Maxime Siemons, Kaat Luyten, Ladan Khodaparast, Laleh Khodaparast, Joan Lecina, Filip Claes, Rodrigo Gallardo, Michel Koole, Meine Ramakers, Joost Schymkowitz, Guy Bormans, Frederic Rousseau
In-silico prediction of in-vitro protein liquid-liquid phase separation experiments outcomes with multi-head neural attention
Daniele Raimondi, Gabriele Orlando, Emiel Michiels, Donya Pakravan, Anna Bratek-Skicki, Ludo Van Den Bosch, Yves Moreau, Frederic Rousseau, Joost Schymkowitz
Donya Pakravan, Emiel Michiels, Anna Bratek-Skicki, Mathias De Decker, Joris Van Lindt, David Alsteens, Sylvie Derclaye, Philip Van Damme, Joost Schymkowitz, Frederic Rousseau, Peter Tompa, Ludo Van Den Bosch
Impact of hydrothermal treatment on denaturation and aggregation of water-extractable quinoa (Chenopodium quinoa Willd.) protein
Julie Van de Vondel, Marlies A. Lambrecht, Joëlle A. J. Housmans, Frederic Rousseau, Joost Schymkowitz, Jan A. Delcour
Food Hydrocolloids Volume 115, June 2021
MAPRE2 mutations result in altered human cranial neural crest migration, underlying craniofacial malformations in CSC-KT syndrome
Cedric Thues, Jorge S Valadas, Liesbeth Deaulmerie, Ann Geens, Amit K Chouhan, Ramon Duran-Romaña, Joost Schymkowitz, Frederic Rousseau, Michaela Bartusel, Rizwan Rehimi, Alvaro Rada-Iglesias, Patrik Verstreken, Hilde Van Esch
Repurposing the antidepressant sertraline as SHMT inhibitor to suppress serine/glycine synthesis addicted breast tumor growth
Shauni Lien Geeraerts, Kim Rosalie Kampen, Gianmarco Rinaldi, Purvi Gupta, Melanie Planque, Nikolaos Louros, Elien Heylen, Kaat De Cremer, Katrijn De Brucker, Stijn Vereecke, Benno Verbelen, Pieter Vermeersch, Joost Schymkowitz, Frederic Rousseau, David Cassiman, Sarah-Maria Fendt, Arnout Voet, Bruno P A Cammue, Karin Thevissen, Kim De Keersmaecker
Drying mode and hydrothermal treatment conditions govern the formation of amyloid-like protein fibrils in solutions of dried hen egg white
MargaritaMonge-Morera, Marlies A. Lambrecht, Lomme J. Deleu, Thibault Godefroidt, Peter Goos, Frederic Rousseau, Joost Schymkowitz, Jan A. Delcour
Food Hydrocolloids Volume 112
Potential human transmission of amyloid β pathology: surveillance and risks
Elsa Lauwers, Giovanna Lalli, Sebastian Brandner, John Collinge, Veerle Compernolle, Charles Duyckaerts, Gustaf Edgren, Stéphane Haïk, John Hardy, Adel Helmy , Adrian J Ivinson, Zane Jaunmuktane , Mathias Jucker, Richard Knight, Robin Lemmens, I-Chun Lin, Seth Love, Simon Mead, V Hugh Perry, James Pickett, Guy Poppy, Sheena E Radford, Frederic Rousseau, Carol Routledge, Giampietro Schiavo, Joost Schymkowitz, Dennis J Selkoe, Colin Smith, Dietmar R Thal, Tom Theys, Pierre Tiberghien, Peter van den Burg, Philippe Vandekerckhove, Clare Walton, Hans L Zaaijer, Henrik Zetterberg, Bart De Strooper
Processing Induced Changes in Food Proteins: Amyloid Formation During Boiling of Hen Egg White
Margarita Monge-Morera, Marlies A Lambrecht, Lomme J Deleu, Rodrigo Gallardo, Nikolaos N Louros, Matthias De Vleeschouwer, Frederic Rousseau, Joost Schymkowitz, Jan A Delcour
Defective SEC61α1 Underlies a Novel Cause of Autosomal Dominant Severe Congenital Neutropenia
Erika Van Nieuwenhove, John S Barber, Julika Neumann, Elien Smeets 3, Mathijs Willemsen 2, Emanuela Pasciuto 2, Teresa Prezzemolo 2, Vasiliki Lagou 2, Laura Seldeslachts 4, Bert Malengier-Devlies 5, Mieke Metzemaekers 6, Sarah Haßdenteufel 7, Axelle Kerstens 8, Rob van der Kant 9, Frederic Rousseau 9, Joost Schymkowitz 9, Daniele Di Marino , Sven Lang, Richard Zimmermann, Susan Schlenner, Sebastian Munck, Paul Proost, Patrick Matthys, Christine Devalck, Nancy Boeckx, Frank Claessens, Carine Wouters, Stephanie Humblet-Baron, Isabelle Meyts, Adrian Liston
Exposure of a Cryptic Hsp70 Binding Site Determines the Cytotoxicity of the ALS-associated SOD1-mutant A4V
Filip Claes, Stanislav Rudyak, Angela S Laird, Nikolaos Louros, Jacinte Beerten, Maja Debulpaep, Emiel Michiels, Rob van der Kant, Joost Van Durme, Greet De Baets, Bert Houben, Meine Ramakers, Kristy Yuan, Serene S L Gwee, Sara Hernandez, Kerensa Broersen, Mikael Oliveberg, Barbara Moahamed, Janine Kirstein, Wim Robberecht, Frederic Rousseau , Joost Schymkowitz
Protein Engineering, Design & Selection : PEDS 32 (10):443-457.
Loss of DPP6 in neurodegenerative dementia: a genetic player in the dysfunction of neuronal excitability
Cacace R, Heeman B, Van Mossevelde S, De Roeck A, Hoogmartens J, De Rijk P, Gossye H, De Vos K, De Coster W, Strazisar M, De Baets G, Schymkowitz J, Rousseau F, Geerts N, De Pooter T, Peeters K, Sieben A, Martin JJ, Engelborghs S, Salmon E, Santens P, Vandenberghe R, Cras P, P De Deyn P, C van Swieten J, M van Duijn C, van der Zee J, Sleegers K, Van Broeckhoven C; BELNEU Consortium
Acta Neuropathol. 137 (6):901-918 2019 Mar 14. doi:10.1007/s00401-019-01976-3
Rational Design of Amyloid-Like Fibrillary Structures for Tailoring Food Protein Techno-Functionality and Their Potential Health Implications
K. J. A. Jansens, I. Rombouts, C. Grootaert, K. Brijs, J. Van Camp, P. Van der Meeren, F. Rousseau, J. Schymkowitz, and J. A. Delcour
Comprehensive Reviews in Food Science and Food Safety, vol. 18, no. 1, pp. 84–105, Nov. 2018.
Hsp90 Mediates Membrane Deformation and Exosome Release
Lauwers E, Wang YC, Gallardo R, Van der Kant R, Michiels E, Swerts J, Baatsen P, Zaiter SS, McAlpine SR, Gounko NV, Rousseau F, Schymkowitz J, Verstreken P
Molecular Dissection of FUS Points at Synergistic Effect of Low-Complexity Domains in Toxicity
Bogaert E, Boeynaems S, Kato M, Guo L, Caulfield TR, Steyaert J, Scheveneels W, Wilmans N, Haeck W, Hersmus N, Schymkowitz J, Rousseau F, Shorter J, Callaerts P, Robberecht W, Van Damme P, Van Den Bosch L
Nuclear inclusion bodies of mutant and wild-type p53 in cancer: a hallmark of p53 inactivation and proteostasis remodeling by p53 aggregation.
De Smet F, Saiz Rubio M, Hompes D, Naus E, De Baets G, Langenberg T, Hipp M, Houben B, Claes F, Charbonneau S, Blanco JD, Plaisance S, Ramkissoon S, Ramkissoon L, Simons C, van den Brandt P, Weijenberg M, Van England M, Lambrechts S, Amant F, D'Hoore A, Ligon KL, Sagaert X, Schymkowitz J, Rousseau F
Alzheimer's-Causing Mutations Shift Aβ Length by Destabilizing γ-Secretase-Aβn Interactions
Szaruga M, Munteanu B, Lismont S, Veugelen S, Horré K, Mercken M, Saido TC, Ryan NS, De Vos T, Savvides SN, Gallardo R, Schymkowitz J, Rousseau F, Fox NC, Hopf C, De Strooper B, Chávez-Gutiérrez L
Phase Separation of C9orf72 Dipeptide Repeats Perturbs Stress Granule Dynamics
Boeynaems S, Bogaert E, Kovacs D, Konijnenberg A, Timmerman E, Volkov A, Guharoy M, De Decker M, Jaspers T, Ryan VH, Janke AM, Baatsen P, Vercruysse T, Kolaitis RM, Daelemans D, Taylor JP, Kedersha N, Anderson P, Impens F, Sobott F, Schymkowitz J, Rousseau F, Fawzi NL, Robberecht W, Van Damme P, Tompa P, Van Den Bosch L
Gallardo R, Ramakers M, De Smet F, Claes F, Khodaparast L1, Khodaparast L, Couceiro JR, Langenberg T, Siemons M, Nyström S, Young LJ, Laine RF, Young L, Radaelli E, Benilova I, Kumar M, Staes , Desager M, Beerens M, Vandervoort P, Luttun A, Gevaert K, Bormans G, Dewerchin M, Van Eldere J, Carmeliet P, Vande Velde G, Verfaillie C, Kaminski CF, De Strooper B, Hammarström P, Nilsson KP, Serpell L, Schymkowitz J, Rousseau F
Sequence-specific protein aggregation generates defined protein knockdowns in plants.
Betti C, Vanhoutte I, Coutuer S, De Rycke RM, Mishev K, Vuylsteke M, Aesaert S, Rombaut D, Gallardo R, De Smet F, Xu J, Van Lijsebettens M, Van Breusegem F, Inzé D, Rousseau F, Schymkowitz J, Russinova E
Structural hot spots for the solubility of globular proteins
Ganesan A, Siekierska A, Beerten J, Brams M, Van Durme J, De Baets G, Van der Kant R, Gallardo R, Ramakers M, Langenberg T, Wilkinson H, De Smet F, Ulens C, Rousseau F, Schymkowitz J
Nat Commun. 2016 Feb 24;7:10816. doi: 10.1038/ncomms10816.
Drosophila screen connects nuclear transport genes to DPR pathology in c9ALS/FTD
Boeynaems S, Bogaert E,, Michiels E,, Gijselinck I,, Sieben A, Jovičić A, De Baets G, Scheveneels W, Steyaert J, Cuijt I, Verstrepen KJ, Callaerts P, Rousseau F, Schymkowitz J, Cruts M, Van Broeckhoven C, Van Damme P, Gitler AD, Robberecht W, Van Den Bosch L
Sci Rep. 2016 Feb 12;6:20877. doi: 10.1038/srep20877.
Post-translational Control of the Temporal Dynamics of Transcription Factor Activity Regulates Neurogenesis.
Quan XJ, Yuan L, Tiberi L, Claeys A, De Geest N, Yan J, van der Kant R, Xie WR, Klisch TJ, Shymkowitz J, Rousseau F, Bollen M, Beullens M, Zoghbi HY, Vanderhaeghen P, Hassan BA.
Protein aggregation as an antibiotic design strategy
Bednarska NG,, Van Eldere J, Gallardo R, Ganesan A, Ramakers M, Vogel I, Baatsen P, Staes A, Goethals M, Hammarström P, Nilsson KP, Gevaert K, Schymkowitz J, Rousseau F
Mol Microbiol. 2015 Nov 12. doi: 10.1111/mmi.13269
Selectivity of Aggregation-Determining Interactions.
Ganesan A, Debulpaep M, Wilkinson H, Van Durme J, De Baets G, Jonckheere W, Ramakers M, Ivarsson Y, Zimmermann P, Van Eldere J, Schymkowitz J, Rousseau F.
Motif discovery with data mining in 3d protein structure databases: discovery, validation and prediction of the u-shape zinc binding ("huf-zinc") motif.
Maurer-Stroh S, Gao H, Han H, Baeten L, Schymkowitz J, Rousseau F, Zhang L, Eisenhaber F.
Molecular plasticity regulates oligomerization and cytotoxicity of the multi-peptide length Aβ pool
Vandersteen A, Masman MF, De Baets G, Jonckheere W, Van der Werf K, Marrink SJ, Rozenski J, Benilova I, De Strooper B, Subramaniam V, Schymkowitz J, Rousseau F, Broersen K.
The mechanism of γ-Secretase dysfunction in familial Alzheimer disease
Chávez-Gutiérrez L, Bammens L, Benilova I, Vandersteen A, Benurwar M, Borgers M, Lismont S, Zhou L, Van Cleynenbreugel S, Esselmann H, Wiltfang J, Serneels L, Karran E, Gijsen H, Schymkowitz J, Rousseau F, Broersen K, De Strooper B
Neurotoxicity of Alzheimer's disease Aβ peptides is induced by small changes in the Aβ42 to Aβ40 ratio.
Kuperstein I, Broersen K, Benilova I, Rozenski J, Jonckheere W, Debulpaep M, Vandersteen A, Segers-Nolten I, Van Der Werf K, Subramaniam V, Braeken D, Callewaert G, Bartic C, D'Hooge R, Martins IC, Rousseau F, Schymkowitz J, De Strooper B.
Exploring the sequence determinants of amyloid structure using position-specific scoring matrices.
Maurer-Stroh S, Debulpaep M, Kuemmerer N, Lopez de la Paz M, Martins IC, Reumers J, Morris KL, Copland A, Serpell L, Serrano L, Schymkowitz JW, Rousseau F.
Analysis of protein processing by N-terminal proteomics reveals novel species-specific substrate determinants of granzyme B orthologs.
Van Damme P, Maurer-Stroh S, Plasman K, Van Durme J, Colaert N, Timmerman E, De Bock PJ, Goethals M, Rousseau F, Schymkowitz J, Vandekerckhove J, Gevaert K.
Genetic variability in progranulin contributes to risk for clinically diagnosed Alzheimer disease.
Brouwers N, Sleegers K, Engelborghs S, Maurer-Stroh S, Gijselinck I, van der Zee J, Pickut BA, Van den Broeck M, Mattheijssens M, Peeters K, Schymkowitz J, Rousseau F, Martin JJ, Cruts M, De Deyn PP, Van Broeckhoven C.
Progranulin genetic variability contributes to amyotrophic lateral sclerosis.
Sleegers K, Brouwers N, Maurer-Stroh S, van Es MA, Van Damme P, van Vught PW, van der Zee J, Serneels S, De Pooter T, Van den Broeck M, Cruts M, Schymkowitz J, De Jonghe P, Rousseau F, van den Berg LH, Robberecht W, Van Broeckhoven C.
Analysis of the transthyretin-like (TTL) gene family in Ostertagia ostertagi - Comparison with other strongylid nematodes and Caenorhabditis elegans.
Saverwyns H, Visser A, Van Durme J, Power D, Morgado I, Kennedy MW, Knox DP, Schymkowitz J, Rousseau F, Gevaert K, Vercruysse J, Claerebout E, Geldhof P.
Lipids revert inert Abeta amyloid fibrils to neurotoxic protofibrils that affect learning in mice.
Martins IC, Kuperstein I, Wilkinson H, Maes E, Vanbrabant M, Jonckheere W, Van Gelder P, Hartmann D, D'Hooge R, De Strooper B, Schymkowitz J, Rousseau F.
Mutations other than null mutations producing a pathogenic loss of progranulin in frontotemporal dementia.
van der Zee J, Le Ber I, Maurer-Stroh S, Engelborghs S, Gijselinck I, Camuzat A, Brouwers N, Vandenberghe R, Sleegers K, Hannequin D, Dermaut B, Schymkowitz J, Campion D, Santens P, Martin JJ, Lacomblez L, De Pooter T, Peeters K, Mattheijssens M, Vercelletto M, Van den Broeck M, Cruts M, et al.
