Preview piece highlights Switch publication in Structure

A Preview written by Lukasz A. Joachimiak highlights our analysis of the key stabilizing interactions within disease-relevant ex vivo amyloid fibres.

How do structural polymorphs arise in the various diseases linked to amyloid fibres formed by the same protein? As it turns out, only a minority of the amino acid residues provide the stability of the amyloid core structure. The rest is up for grabs and can form several, energetically similar conformations.

Read “The interactions that shape amyloid fibrils in disease” by Lukasz A. Joachimiak here.

You can find the publication of van der Kant et al. here.