Welcome to the Switch Laboratory

Mapping aggregation-specific interactions in human disease

Our research focuses on understanding the mechanisms gearing protein folding and misfolding and their relation to human disease. In particular, we are investigating how protein aggregation affects the interactome by suppressing native interactions but also by introducing novel aggregation-specific interactions. These latter are especially relevant as they are usually associated with gain of function activities such as neurotoxicity (neurodegeneration).

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Newest publications

  • publication

    Energetic profiling reveals thermodynamic principles underlying amyloid fibril maturation

    Ramon Duran-Romaña, Joost Schymkowitz, Frederic Rousseau, Nikolaos Louros
    Nat Commun 2025 Nov 18
    PubMed
  • publication

    A versatile platform for combinatorial antibody library cloning and NGS-based quality control with high accuracy

    Zhongyao Zhang, Simon D'Hondt, Rob Van der Kant, Guy Hermans, Nick Geukens, Vitor Bernardes Pinheiro, Joost Schymkowitz, Frederic Rousseau, Maarten Dewilde
    Nucleic Acids Res . 2025 Oct 14
    PubMed
  • publication

    Toward a thermodynamic taxonomy of amyloid fibrils

    Nikolaos Louros, Joost Schymkowitz, Frederic Rousseau
    Structure 2025 Oct 2
    PubMed
  • publication

    [11C]HSP990 PET as a translational tool to investigate the role of Hsp90 in tumours and support the development of Hsp90 therapeutics

    Romy Cools, Valeria Narykina, Koen Vermeulen, Sanket J Mishra, Brian S J Blagg, Marleen Derweduwe, Frederik De Smet, Aaron Ziani-Zeryouh, Matteo Riva, An Coosemans, Frederic Rousseau, Joost Schymkowitz, Guy Bormans
    EJNMMI Radiopharm Chem. 2025 Sep 26
    PubMed
  • publication

    AXZ viewer: a web application to visualize unprocessed AFM‑IR data

    Wouter Duverger, Georg Ramer, Nikolaos Louros, Joost Schymkowitz, Frederic Rousseau
    Bioinformatics 2025 Sep 19
    PubMed
  • publication

    Chemical Synthesis of Medin via a Removable Aggregation-Suppressing Linker

    Matthias De Vleeschouwer, Brajabandhu Pradhan, Frederic Rousseau, Joost Schymkowitz
    J Pept Sci 2025 Aug
    PubMed