Welcome to the Switch Laboratory

Mapping aggregation-specific interactions in human disease

Our research focuses on understanding the mechanisms gearing protein folding and misfolding and their relation to human disease. In particular, we are investigating how protein aggregation affects the interactome by suppressing native interactions but also by introducing novel aggregation-specific interactions. These latter are especially relevant as they are usually associated with gain of function activities such as neurotoxicity (neurodegeneration).

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Newest publications

  • publication

    Emergence of the B.1.214.2 SARS-CoV-2 lineage with an Omicron-like spike insertion and a unique upper airway immune signature

    Andrew Holtz, Johan Van Weyenbergh, Samuel L Hong, Lize Cuypers, Áine O'Toole, Gytis Dudas, Marco Gerdol, Barney I Potter, Francine Ntoumi, Claujens Chastel Mfoutou Mapanguy, Bert Vanmechelen, Tony Wawina-Bokalanga, Bram Van Holm, Soraya Maria Menezes, Katja Soubotko, Gijs Van Pottelbergh, Elke Wollants, Pieter Vermeersch, Ann-Sophie Jacob, Brigitte Maes, Dagmar Obbels, Veerle Matheeussen, Geert Martens, Jérémie Gras, Bruno Verhasselt, Wim Laffut, Carl Vael, Truus Goegebuer, Rob van der Kant, Frederic Rousseau, Joost Schymkowitz, Luis Serrano, Javier Delgado, Tom Wenseleers, Vincent Bours, Emmanuel André, Marc A Suchard, Andrew Rambaut, Simon Dellicour, Piet Maes, Keith Durkin, Guy Baele
    BMC Infect Dis . 2024 Oct
    PubMed
  • publication

    A core proteome profile unites mouse models and patients in Alzheimer disease

    Tsaka G, Rousseau F, Schymkowitz J
    Cell Rep Med. 2024 Aug 20
    PubMed
  • publication

    An end-to-end approach for single-cell infrared absorption spectroscopy of bacterial inclusion bodies: from AFM-IR measurement to data interpretation of large sample sets

    Wouter Duverger, Grigoria Tsaka, Ladan Khodaparast, Laleh Khodaparast, Nikolaos Louros, Frederic Rousseau, Joost Schymkowitz
    J Nanobiotechnology . 2024 Jul 10
    PubMed
  • publication

    Pharmacological modulation of septins restores calcium homeostasis and is neuroprotective in models of Alzheimer's disease

    Katrien Princen , Tom Van Dooren, Marit van Gorsel, Nikolaos Louros, Xiaojuan Yang, Michael Dumbacher, Ilse Bastiaens, Kristel Coupet, Shana Dupont, Eva Cuveliers, Annick Lauwers, Mohamed Laghmouchi, Thomas Vanwelden, Sofie Carmans, Nele Van Damme, Hein Duhamel, Seppe Vansteenkiste, Jovan Prerad, Karolien Pipeleers, Olivier Rodiers, Liese De Ridder, Sofie Claes, Yoni Busschots, Lentel Pringels, Vanessa Verhelst, Eveline Debroux, Marinka Brouwer, Sam Lievens, Jan Tavernier, Melissa Farinelli, Sandrine Hughes-Asceri, Marieke Voets, Joris Winderickx, Stefaan Wera, Joris de Wit, Joost Schymkowitz, Frederic Rousseau, Henrik Zetterberg, Jeffrey L Cummings, Wim Annaert, Tom Cornelissen, Hans De Winter, Koen De Witte, Marc Fivaz, Gerard Griffioen
    Science . 2024 May 31
    PubMed
  • publication

    CORDAX web server: An online platform for the prediction and 3D visualization of aggregation motifs in protein sequences

    Nikolaos Louros, Frederic Rousseau, Joost Schymkowitz
    Bioinformatics . 2024 Apr 25
    PubMed
  • publication

    Mechanistic insights into the adaptive evolvability of spore heat resistance in Bacillus cereus sensu lato

    Sadhana Khanal, Tom Dongmin Kim, Katrien Begyn, Wouter Duverger, Gertjan Kramer, Stanley Brul, Andreja Rajkovic, Frank Devlieghere, Marc Heyndrickx, Joost Schymkowitz, Frederic Rousseau, Véronique Broussolle, Chris Michiels, Abram Aertsen
    Int J Food Microbiol . 2024 Apr 15
    PubMed